Purpose and strategy
The internal
disorder covers disorders related to specific organs such as the heart,
the kidny, the bladder, and the small intestine, and there are no personal devices
for examining the health condition of these persons according to
individual needs. This aim is to develop a simple immunoassay system for internally handicapped people to manage and maintain daily health status.
As a means to realize it, we focused on an immunoassay system using surface plasmon resonance (SPR). By
immobilizing antibodies on the surface of the detection part of the
system, we aim to detect trace substances such as proteins in the blood.
Original Papers (English)
- S. Toyama and Y. Ikariyama, Design and Characterization of Polymer Matrix Anchored to Gold Thin Layer for the Effective Usage of Evanescent Field in SPR-based Immunosensor, Chemistry Letters, 1997, 1083-1084.
- S. Toyama, A. Shoji, Y. Yoshida, S. Yamauchi, and Y. Ikariyama, Surface design of SPR-based immunosensor for the effective binding of antigen or antibody in the evanescent field using mixed polymer matrix, Sensors and Actuators B, 52, 65-71 (1998).
- S. Toyama, N. Doumae, A. Shoji, Y. Ikariyama, Design and fabrication of a waveguide-coupled prism device for surface plasmon resonance sensor, Sensors and Actuators B, 65, 32-34 (2000).
- A. Shoji, S. Toyama, Y. Yoshida, S. Yamauchi, Y. Ikariyama, SPR Sensor as a Tool to Evaluate Binding Capacity of Gastric Ulcer Drugs with Mucous Membrane,IEEJ Transactions on Sensors and Micromachines, 121-E(8), 469-470 (2001).
- S. Toyama, O. Takei, M. Tsuge, R. Usami, K. Horikoshi, S. Kato, Surface plasmon resonance of electrochemically deposited Au-black, Electrochem. Commun. 4, 540-544 (2002).
- S. Toyama, K. Aoki, S. Kato, SPR observation of adsorption and desorption of water-soluble polymers on an Au surface, Sensors and Actuators B, 108, 903-909 (2005).
- K. Aoki, S. Kato, S. Toyama, Nonspecific Dtection of Proteins by the Use of Electrochemical SPR Sensor, Electrochemistry, 74, 189-191 (2006).